Coupled structural transitions enable highly cooperative regulation of human CTPS2 filaments
Coupled structural transitions enable highly cooperative regulation of human CTPS2 filaments 3Many enzymes assemble into defined oligomers, providing a mechanism for cooperatively regulating activity. Recent studies have described a mode of regulation in which enzyme activity is modulated by polymerization into large-scale filaments. Here we describe an ultrasensitive form of polymerization-based regulation employed by human CTP …
News story posted on 2019-12-23T20:49:00.0000000Z